Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis

Generalized pustular psoriasis with a novel mutation of interleukin-36 receptor antagonist, responding to methotrexate.

GPP: generalized pustular psoriasis IL-36RN: interleukin-36 receptor antagonist PV: psoriasis vulgaris INTRODUCTION Generalized pustular psoriasis (GPP) is a rare but serious inflammatory skin disease that may be caused by deficiency of interleukin-36 receptor antagonist in which there is presence of homozygous or compound heterozygous mutations of the IL-36RN gene. Most GPP cases are sporadic,...

Acute Pustular Psoriasis

was stable, his skin became irritable and hot with extensive reddening. Though in bed in a warm room he felt cold. During the next three days the skin became tender, and large areas of pustulation developed. Subsequently there was widespread peeling of the skin, and crusting developed on the face and neck. On admission to hospital there was generalized cutaneous erythema and scleral jaundice. T...

Childhood pustular psoriasis: case report.

Generalized pustulous psoriasis is a rare type of psoriasis first described in 1910 by Von Zumbusch. This disease tends to have a more benign development in children when compared to its development in adults. However, in its serious form it may represent a risk to the patient's life. Maybe, due to being such a rare disease no therapeutic option has so far consistently proved to be both effecti...

Spongiform pustules of Kagoj in Psoriasis = تارثبلا ةيجنفسالا لكشلا يف فدصلا Psoriasis Psoriasis may be divided into psoriasis vulgaris, generalized pustular psoriasis, and localized pustular psoriasis. Psoriasis Vulgaris Clinical Features

Pustular psoriasis: pathophysiology and current treatment perspectives

Psoriasis vulgaris is a chronic inflammatory disease that classically affects skin and joints and is associated with numerous comorbidities. There are several clinical subtypes of psoriasis including the uncommon pustular variants, which are subdivided into generalized and localized forms. Generalized forms of pustular psoriasis include acute generalized pustular psoriasis, pustular psoriasis o...